Influence of IS 256 on Genome Variability and Formation of Small-Colony Variants in Staphylococcus aureus

Small-colony variants of Staphylococcus aureus.

Staphylococcus aureus remains a versatile and dangerous pathogen. Small-colony variants (SCVs) of S. aureus are a naturally occurring sub-population, first described nearly 100 years ago. These variants, of which there are different classes, grow slowly and have many atypical characteristics thought to be due to defective electron transport, and include minute colony forms. SCVs have been isola...

Small Colony Variants of Staphylococcus aureus and Pacemaker-related Infection

I caused by Staphylococcus aureus range from mild skin infections to acute life-threatening diseases such as pneumonia, osteomyelitis, and endocarditis. However, S. aureus may also cause a chronic disease with persistent and recurrent infections. Skin and soft tissue infections, chronic osteomyelitis, and persistent infections in patients with cystic fibrosis have been associated with small col...

Staphylococcus aureus small colony variants in diabetic foot infections

Background : Staphylococcus aureus (S. aureus) is one of the major pathogens causing chronic infections. The ability of S. aureus to acquire resistance to a diverse range of antimicrobial compounds results in limited treatment options, particularly in methicillin-resistant S. aureus (MRSA). A mechanism by which S. aureus develops reduced susceptibility to antimicrobials is through the formation...

Small colony variants in Staphylococcus aureus and other species: antibiotic selection, antimicrobial susceptibility, and biofilm formation

Methicillin-Resistant Staphylococcus aureus (MRSA) Triclosan Small Colony Variants

variants (SCVs) !" sub-MIC triclosan (TLN) # $ %& ' ( !) TLN SCVs*"+,!" "+#. 2 $'(/0 %1, 4 $ . &' 2&34$56* SCVs (7,68!" %9: SCVs;. MIC*)< * 25+= ;',$ >DNase .? @ABCDEF/ G4H0IJKLM12 3NO * 4$ PQ R( 5S6TU7V:9!" =! TLN WDXYZ;R enoyl reductase enzyme (FabI) Ala95[ValU,\. Thr147[His A]^_(` /a68!" TLN SCVs. b 886c9:;,6U *? =;o@,!"A '...